Date of Submission
Spring 2020
Academic Program
Chemistry
Project Advisor 1
Emily McLaughlin
Abstract/Artist's Statement
Nitrogen is an important element in many molecules and nitrenes have been a way to introduce nitrogen into molecules. Dubois’ research group shows through their work, the importance of carbamates in nitrene insertion reactions. The focus of this research project will be creating the precursor for the synthetic process of nitrene-mediated ylide intermediate formation. From this ylide intermediate, a nitrene insertion/[3+2] cycloaddition will form polycyclic compounds that can be used for a variety of synthetic applications. To create this precursor, the synthetic process requires 6 steps starting from 1,3-propanediol to finally the carbamate precursor. The significance of creating this precursor is to utilize nitrene transfer chemistry, a developing field of study, and to create new complex compounds for various potential uses.
Open Access Agreement
On-Campus only
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.
Recommended Citation
Lee, Brian, "Investigation of a Nitrene Promoted [3 + 2] Cycloaddition: Progress toward Carbamate Substrate Design and Synthesis" (2020). Senior Projects Spring 2020. 1.
https://digitalcommons.bard.edu/senproj_s2020/1
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