Date of Submission
Spring 2024
Academic Program
Chemistry and Biochemistry
Project Advisor 1
Swapan Jain
Abstract/Artist's Statement
This study investigates the interactions between two ruthenium (II) complexes, namely LM5400 and Compound B, with DNA:RNA hybrids—an area of the human genome primed for exploration. Building upon the Jain lab’s insights into Cisplatin’s effects on hybrids, our research aims to uncover the therapeutic potential of these compounds. Employing a multidisciplinary approach integrating advanced techniques and assays such as CRISPR, gel electrophoresis, electrophoretic mobility shift assay, and UV-Vis melting studies, we seek to decipher the underlying molecular mechanisms of these interactions. This study may potentially represent a significant advancement in nucleic acid chemistry, with implications for reshaping biomedical research and clinical interventions aimed at diseases where DNA:RNA hybrids play a critical role.
Open Access Agreement
On-Campus only
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.
Recommended Citation
Omi, Fuadur Rahman, "Investigating the Binding Potential of Ruthenium (II) Based Metal Complexes to DNA:RNA Hybrids" (2024). Senior Projects Spring 2024. 214.
https://digitalcommons.bard.edu/senproj_s2024/214
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