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(This information was taken from the Distinguished Scientist Lecture Series Program 1989-1990).
Dr. Wolfe, the Chown Research Professor ofChemistry at Queen's University, Kingston, Ontario, is the author of over 200 scientific papers and holds over 30 patents, including one for the commercial production of the drug ampicillin. He is co- author of the monograph Theoretical Physical Organic Chemistry to be published by John Wiley & Sons in 1990. Professor Wolfe earned his B.A. and M.A. degrees from the University of Toronto and his Ph.D. from the University of Ottawa. He completed post-doctoral studies at the Weizmann Institute in Israel before joining the pharmaceutical division of Bristol-Myers. In his 28 years at Queen's University he has conducted research in drug design and has pioneered strategies which use biotechnology to reduce the time involved in the synthesis of new drugs. He has also addressed the theoretical aspects of the structure and reactivity of large molecules, specifically with regards to interactions between drugs and their receptors. Professor Wolfe's research efforts have been recognized by his election as a fellow of both the Chemical Institute of Canada and the Royal Society of Canada, by the Merck Award for outstanding achievement in organic chemistry, and by the Queen's University Prize for Excellence in Research. Professor Wolfe has lectured world-wide on topics ranging from pharmaceuticals to theoretical chemistry. Many of his former students hold professorships at major universities in the U.S., Canada, and Europe, and his research collaborators span the globe.
His Work: Professor Wolfe's recent publications describe strategies for peptide conformational analysis as applied to receptor sites in drug design. Applications of these procedures have resulted in structure-activity relationships for penicillin and anti-convulsant drugs, among others.
March 17, 1990
Wolfe, Saul, "Drug-Receptor Interactions: A Chemist's Approach" (1990). DSLS 1989-1990. 6.