Chemistry of a Simple Behavioral System'

Chemistry of a Simple Behavioral System'


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(This information was taken from the Distinguished Scientist Lecture Series Program 1987-1988).

Dr. Koshland is professor of biochemistry at the University of California at Berkeley and editor of Science magazine. Born in New York City, Dr. Koshland earned the B.S. degree from the University of California at Berkeley, and the Ph.D. degree from the University of Chicago. After two postdoctoral years at Harvard University, he joined the staff of Brookhaven National Laboratory and held joint appointments at Rockefeller University and Brookhaven until 1965, when he joined the faculty at the University of California at Berkeley. Dr. Koshland is a member of the National Academy of Sciences, the American Academy of Arts and Sciences, the American Chemical Society, and the American Society of Biological Chemists, where he has served as president. Among his honors are the Edgar Fahs Smith Award and the Pauling Award of the American Chemical Society, the Rosenstiel Award of Brandeis University, and the T. Duckett Jones Award of the Helen Hay Whitney Foundation. He has been a Guggenheim Fellow and a Visiting Fellow of All Souls College at Oxford University, and was elected an honorary foreign member of the Japanese Biochemical Society and the Royal Swedish Academy of Sciences. As founding member and chairman of the Academy Forum, a committee of the National Academy of Sciences, he helped develop policy on issues that pose dilemmas between science and societal problems. Currently chairman of the editorial board of the Proceedings of the National Academy of Sciences, Dr. Koshland has served on the editorial boards of Accounts of Chemical Research, The Journal of Biological Chemistry, and the Journal of Molecular Biology.

His Work: Dr. Koshland's early work focused on enzyme mechanisms and protein chemistry leading to the concept of single and double displacement reactions, the development of reagents for carboxyl groups and tryptophan, and the analysis of factors explaining the high catalytic power of enzymes. This work led to his concept of the induced fit theory, the general work on cooperativity mechanisms, and the discovery of negative cooperativity. His recent work has focused on mechanisms of behavior using bacterial chemotaxis as a model system.

His Lecture April 30, 1988: "Chemistry of a Simple Behavioral System"



Creation Date

April 30, 1988

Chemistry of a Simple Behavioral System'