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Valproic acid, or VPA, is a drug used in the treatment of epileptic seizures and one with potential for further clinical use. Importantly, both in a biological and medical context, it is interesting and important to study the effect of this drug on synaptic plasticity. In this study, the aim was to gain an understanding for the effects of VPA on synaptic plasticity in Xenopus laevis tadpoles through the analysis of optomotor response behavior. To do this, tadpoles were exposed to VPA, then exposed to a visual stimulus, and the optomotor response behavior was recorded and analyzed. Overall, I established a successful and reliable protocol for testing the effects of VPA on synaptic plasticity and found Xenopus laevis to be a reliable model for future testing on this subject.
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Mordecai, Rachel Ani, "The Effects of Valproic Acid on the Optomotor Response Behavior in Xenopus laevis Tadpoles" (2020). Senior Projects Spring 2020. 92.
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