Date of Submission

Spring 2019

Academic Programs and Concentrations

Chemistry

Project Advisor 1

Dr. Swapan Jain

Abstract/Artist's Statement

The thermal stability of platinum based chemotherapeutic agents

Cisplatin, Oxaliplatin and Carboplatin interaction with 10 basepair DNA/RNA duplexes and hybrids was investigated. UV-Spectroscopy was used to measure the enthalpy, entropy, melting temperature, free energy, and binding stoichiometry of DNA/RNA duplexes and hybrids denaturation in the existence and the absence of Cisplatin, Oxaliplatin and Carboplatin. Isothermal Titration Calorimetry was used to measure the enthalpy, entropy, free energy, association/dissociation constants and stoichiometry of DNA/RNA duplexes and hybrids formation in the presence and the absence of Cisplatin, Oxaliplatin and Carboplatin.

Open Access Agreement

Open Access

Creative Commons License

Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.

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