Date of Submission
Academic Programs and Concentrations
Project Advisor 1
Dr. Swapan Jain
The thermal stability of platinum based chemotherapeutic agents
Cisplatin, Oxaliplatin and Carboplatin interaction with 10 basepair DNA/RNA duplexes and hybrids was investigated. UV-Spectroscopy was used to measure the enthalpy, entropy, melting temperature, free energy, and binding stoichiometry of DNA/RNA duplexes and hybrids denaturation in the existence and the absence of Cisplatin, Oxaliplatin and Carboplatin. Isothermal Titration Calorimetry was used to measure the enthalpy, entropy, free energy, association/dissociation constants and stoichiometry of DNA/RNA duplexes and hybrids formation in the presence and the absence of Cisplatin, Oxaliplatin and Carboplatin.
Open Access Agreement
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.
Al Rubaye, Humam Jaafar, "THERMODYNAMIC INVESTIGATION OF THE BINDING OF PLATINUM BASED COMPLEXES WITH 10 BASEPAIR DNA/RNA STRUCTURES" (2019). Senior Projects Spring 2019. 143.