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The thermal stability of platinum based chemotherapeutic agents
Cisplatin, Oxaliplatin and Carboplatin interaction with 10 basepair DNA/RNA duplexes and hybrids was investigated. UV-Spectroscopy was used to measure the enthalpy, entropy, melting temperature, free energy, and binding stoichiometry of DNA/RNA duplexes and hybrids denaturation in the existence and the absence of Cisplatin, Oxaliplatin and Carboplatin. Isothermal Titration Calorimetry was used to measure the enthalpy, entropy, free energy, association/dissociation constants and stoichiometry of DNA/RNA duplexes and hybrids formation in the presence and the absence of Cisplatin, Oxaliplatin and Carboplatin.
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Al Rubaye, Humam Jaafar, "THERMODYNAMIC INVESTIGATION OF THE BINDING OF PLATINUM BASED COMPLEXES WITH 10 BASEPAIR DNA/RNA STRUCTURES" (2019). Senior Projects Spring 2019. 143.