Date of Submission

Spring 2015

Academic Programs and Concentrations

Biology; Chemistry

Project Advisor 1

Craig Anderson

Project Advisor 2

Brooke Jude

Abstract/Artist's Statement

Cisplatin is a commonly used chemotherapeutic drug with a platinum metal center. While it is effective as an anti-cancer agent, it also has a host of unwanted side-effects. A possible cause of some side-effects may be due to the lack of selectivity of cisplatin, therefore research to find an alternative that is not only less cytotoxic to normal cells but also more likely to specifically target cancer cells has intensified. The compounds in this study contain two metal centers, both ruthenium and iron. The ruthenium center may help facilitate specificity and may have an anti-metastasis effect. The iron core may act as a cytotoxic moiety of the compound. Overall the compounds are expected to have lower toxicity to normal cells. Three ruthenium-ferrocene compounds were synthesized and tested in biological assays for cytotoxic and anti-metastatic effects.

Open Access Agreement

On-Campus only

Creative Commons License

Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License.

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