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Autism spectrum disorders (ASDs) are defined by three characteristics: social deficits, communication impairment, and repetitive behaviors. Though many genes have been implicated in autism susceptibility studies, none had been shown to account for more than a small percentage of cases until the identification of the DIA1, or Deleted in Autism 1, family of genes, for which homozygous deletions are consistent with classical autism. Homologues of DIA1 and DIA1R, or Deleted in Autism 1 Related have been found in Danio rerio. DIA1R is lacking in fish considered solitary by nature and present in what are considered schooling fish. Here, the expression of LOC569232, a DIA1R homologue, was traced throughout development of Danio rerio using RT-PCR. In situ hybridization was also performed to visualize where LOC569232 transcripts are localized.
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Dick, Shellie Ann, "Characterization of LOC569232, a Deleted in Autism 1-Related homologue and a putative determinant of shoaling behavior in Danio rerio, the zebrafish" (2012). Senior Projects Spring 2012. 138.
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