Simulating an Immune Response with a Combined Agent-Based Model of a Triple-Negative Breast Cancer Tumor and Vascular Network
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Cytotoxic T-cells (CTLs) are one mechanism the immune system employs to eliminate cancer cells. In this study, I expand upon a previous 3-dimmensional agent-based model of triple-negative breast cancer to include a therapy simulating an immune response in the form of a CTL insertion into the tumor. The model consists of the tumor, comprised of progenitor cells, cancer stem cells, and tumor-associated macrophages, as well as an expanding vascular network. I investigate the effects of inserting different amounts of CTLs into the space, and their effect on tumor size in the short and longer terms. The results show that while CTLs decrease the size of the tumor they are ineffective at completely eliminating it, leading to continued tumor proliferation in the aftermath
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Ventoso, Michael J., "Simulating an Immune Response with a Combined Agent-Based Model of a Triple-Negative Breast Cancer Tumor and Vascular Network" (2019). Senior Projects Fall 2019. 31.
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