Date of Submission
Spring 2012
Academic Program
Chemistry; Biology
Project Advisor 1
Craig Anderson
Project Advisor 2
Michael Tibbetts
Abstract/Artist's Statement
AH197 and IT127 are two novel compounds, containing both ruthenium(III) and platinum(II) centers, that are designed to incorporate the properties of established anticancer agents with different modes of action in their attack on cancer cells. The synthesis of hetero-multinuclear compounds as chemotherapeutic agents is an area that has not been explored extensively, though therapy utilizing a combination of different drugs is a common practice, especially in the treatment of advanced cancers. The goals of this project are to synthesize new compounds like AH197 and IT127, and to develop techniques that properly assess their potential as anticancer agents. The adducts of these compounds with serum proteins have been characterized by UV/visible as well as X-ray absorption spectroscopy, suggesting that adduct formation occurs via chloride substitution at ruthenium(III) centers, but not ruling out the reduction from ruthenium(III) to ruthenium(II). Assays of motility inhibition by these compounds in a breast cancer cell line, MDA-MB-231 have been performed as well as assays of electrophoretic mobility of DNA-compound adducts. While IT127 is shown to outperform the clinical cancer drug, cisplatin in inhibition of DNA mobility, AH197 shows great potential as an antimetastatic drug, in comparison to a ruthenium(III) drug in clinical trials, NAMI-A. It is clear that these compounds demonstrate good potential as anticancer agents with possibly low general toxicity, making them promising as selective chemotherapeutics.
Distribution Options
Access restricted to On-Campus only
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License.
Recommended Citation
Taylor, Isabelle, "Synthesis and Characterization of Hetero-Multinuclear Ruthenium/Platinum Complexes and Assessment of Their Potential as Anticancer Agents" (2012). Senior Projects Spring 2012. 205.
https://digitalcommons.bard.edu/senproj_s2012/205
This work is protected by a Creative Commons license. Any use not permitted under that license is prohibited.
Bard Off-campus DownloadBard College faculty, staff, and students can login from off-campus by clicking on the Off-campus Download button and entering their Bard username and password.